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Am J Dig Dis
Once it enters the cytoplasm, a part of Cu + binds to glutathione (GSH) and is delivered to metallothionein 1/2 (MT1/2) to be restored, and other parts of Cu + are either transferred to the nucleus or ATP7A/7B located in the trans-Golgi network (TGN) by the chaperone antioxidant-1(ATOX1) to facilitate the synthesis of cuproenzymes (Lutsenko et al., 2007) or delivered to superoxide dismutase 1 (SOD1) in the cytoplasm and mitochondrial intermembrane space by a copper chaperone for superoxide dismutase (CCS) to detoxify reactive oxygen species (ROS)
Multiple reviewers report orders that took weeks to arrive, packages with no tracking information, and medications that arrived warm or improperly packaged
Current Opinion in Biotechnology, 65 , 118-128
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