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For immunohistochemistry, colonic biopsy tissue was collected from individuals with Crohns disease undergoing routine colonoscopy and volunteers (controls) undergoing colon cancer screening (ethics ID REB24827)

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GLP-1RA could not only facilitate the M2 polarization of microglia through both direct and indirect pathways, but also modulate the quantity and function of T cell subtypes, including CD4, CD8, and regulatory T cells, resulting into the inhibition of inflammatory responses and the promotion of neuronal regeneration through interleukin-10 secretion