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While litigation involving these drugs is ongoing, the claims have raised important questions about how GLP-1 medications affect the digestive system and what patients should know about potential risks

Follow the dosage escalation in Table 1 to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.6), Adverse Reactions (6.1)]

But despite the lower hunger, and greater satiety, food intake throughout the day was not significantly affected

A recent analysis calculated an estimated number needed to harm of 1,066 associated with a DPP-4 inhibitor therapy (12, 4749)

The downstream release of these three factors, in response to GLP-1R activation, leads to glucose-dependent insulin release