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The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data

Zhu B, Xu S, Zhang J et al (2024) Rosmarinic acid mitigates intestinal inflammation and oxidative stress in bullfrogs ( Lithobates catesbeiana ) fed high soybean meal diets

Sragovich S, Merenlender-Wagner A, Gozes I

For children , Ill often add extra vitamin C and/or zinc to their multivitamins to support the antioxidant network if they are taking Tylenol for more than a day or two

More entrenched problems often require several weeks to months of consistent treatment plus rehab before the changes feel significant