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BLU-945, a selective EGFR inhibitor, was tested in EGFR-mutated NSCLC (NCT04862780), while daraxonrasib, a RAS(ON) multiselective noncovalent tri-complex inhibitor, is being evaluated in both NSCLC (NCT06881784) and PDAC (NCT06625320)
However, three subsequent randomized control trials reported a neutral effect in airway inflammation with both available TZDs, pioglitazone and rosiglitazone
10.1038/s41569-021-00605-5 80 ShahS
Beuschlein, S
FDA-approved tirzepatide products (Mounjaro, Zepbound) are commercially available
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