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Muscogiuri G, Barrea L, Di Somma C, Altieri B, Vecchiarini M, Orio F, et al

Figure 2 illustrates schematically some documented changes: rhythms of locomotor activity (rest-activity cycle), core body temperature, hormone secretion (e.g., melatonin at night, cortisol in the morning), SCN neuronal firing rate, and even daily metabolic indicators like plasma glucose all show diminished oscillation amplitudes in older adults compared to younger adults

doi: 10.1128/IAI.72.2.1155-1158.2004 18 HoelzerK.MorenoS

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Each guide includes the clinical trial titration used in published studies