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study demonstrated that ipamorelin: Released GH in a dose-dependent manner Did not significantly elevate cortisol levels, even at high doses Did not significantly elevate prolactin levels Did not significantly affect ACTH, FSH, LH, or TSH (4) This selectivity gives ipamorelin a notably clean side-effect profile compared to other GH secretagogues

However, avoid layering strong actives like retinoids or exfoliating acids at the same time unless your skin tolerates them, as this may increase sensitivity

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Ipamorelin functions through activation of the growth hormone secretagogue receptor (GHS-R1a), commonly known as the ghrelin receptor