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Even if administered separately, co-administration without formal pharmacokinetic and pharmacodynamic evaluation cannot be considered safe

Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and -synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain

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Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases