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Some individuals maintain 60-70% of their weight loss for 1-2 years through sustained behavior change

A comprehensive analysis of clinical and preclinical data reveals that GLP-1 receptor agonists, previously suspected of increasing cancer risk, are generally safe and may even reduce the incidence of certain cancers through improved insulin regulation and immune modulation

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With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (64, 66, 67) ( Figures 1AC )

Third, documentation of side effects enables early recognition of adverse events that may require intervention, such as persistent nausea, dehydration, or signs of pancreatitis