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Splitting the dose reduces peak neurotransmitter fluctuation
The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)
The midbrain is also home to serotonergic neurons of the dorsal raphe nucleus (DRN), which sends widespread ascending and descending projections throughout the brain
They can help determine the cause and find a solution, which might involve adjusting your dose or trying a different medication
Refrigerate Immediately: The reconstituted vial must be stored in a refrigerator, typically between 2C and 8C (36F and 46F)
