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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism

Office of Dietary Supplements, US National Institutes of Health

In this study, both AOD9604 and HA individually led to improved cartilage outcomes and shorter periods of lameness compared to saline control

PMC 6470702

5-Amino-1MQ is an investigational small molecule studied for its possible effects on NNMT, metabolism, fat cell activity, NAD-related pathways, and healthy aging