Taken together, these pooled safety analyses (119123) and CV outcome safety trials (124127), together with review of published data from numerous clinical trials (39), provide reassuring evidence that the catalytic activity of the DPP-4 molecule can be modulated to enhance the beneficial metabolic effects of its substrates (such as the incretin hormones) without adversely affecting any of the protease-independent metabolic effects discussed above, or interfering with any of its other (non-metabolic) functions
Gastroparesis causes abdominal distension, which makes it easier for stomach acid to escape out of the top of your stomach into your esophagus
Oxidative stress activates apoptotic pathways, impairing the DNA repair capacity of sperm, thereby transmitting damaged genetic material to the embryo during fertilization [65, 66]
PT-141 is one of the most effective tools available for restoring central sexual function, but only when used intelligently
Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas