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Side effects Most common: nausea, vomiting, diarrhea, constipation, abdominal discomfort, headache, fatigue, injection-site reactions
Consent to participate Written informed consent to participate in this case report was obtained from the patient
The Phase 2 trial of retatrutide (Jastreboff et al., New England Journal of Medicine , 2023) reported that the most common adverse effects were gastrointestinal in nature (nausea, vomiting, diarrhoea), consistent with the GLP-1 receptor agonist class
However, Klein et al.s [142] research revealed that, despite inducing an elevation in serum GDF15 levels, metformin promotes weight loss via GDF15GFRAL-independent mechanisms in mice and humans
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