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One explanation is that while antioxidants can initially protect cells, prolonged exposure might deplete intracellular antioxidant reserves and make cells more susceptible to damage
DOI: 10.3389/fendo.2024.1431292 [Google Scholar] Armstrong MJ, Gaunt P, Aithal GP, Barton D, Hull D, Parker R, et al
This leads to sagging, fine lines, and dullness
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The effective concentration in cellular assays is 10 to 100 nM, with loss of efficacy at higher concentrations
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