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Increased ATP/ADP ratio induces the closure of ATP-sensitive potassium (K ATP ) channels, leading to membrane depolarization followed by activation of voltage-gated Ca 2+ channels (VGCC) and Ca 2+ influx
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It requires neurotrophic support, reduced inflammation, and sufficient neural substrate, meaning enough surviving and newly generated neurons to form the new pathways needed for functional recovery
For instance, both stress (or synthetic glucocorticoids) and poor nutrition in utero can have significant long-term consequences for feeding and behavior
NAC is also an antioxidant itself as a source of sulfhydryl groups in cells and scavenger of free radicals as it interacts with reactive oxygen species such as OH and H 2 O 2 60
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