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Tirzepatide, a dual GIP and GLP-1 receptor agonist marketed as Mounjaro and Zepbound, demonstrates substantial weight reduction in clinical trials, yet most patients experience periods where weight loss slows or temporarily stalls
A nervous system stuck in fight or flight tends to slow digestion and can worsen constipation
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Reactive oxygen species have a causal role in multiple forms of insulin resistance
In the Phase 2 trial, retatrutide 12 mg weekly produced mean weight loss of 24.2% at 48 weeks, with the highest-dose group achieving 28.7% at the same timepoint in the TRIUMPH-4 Phase 3 trial
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