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L-carnitine is made in the human brain, liver, and kidneys by amino acids, lysine, and methionine
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Without effective treatments, it is still difficult to demonstrate that such biomarkers could reliably predict therapeutic efficacy or outcomes
Gros, L., Hollande, F., Thorens, B., Kervran, A
In particular, ensuring adequate CNS exposure, maintaining appropriate isoform selectivity margins, and establishing a tolerable safety profile are essential requisites for its development as a drug (Al-Nema et al., 2021)
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