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There is no diet or exercise program shown to sustain long-term weight loss for those with obesitymedical therapies are usually necessary

We found a significant fold increase in the levels of several tumor suppressor and DNA repair gene protein products (GP)s at the end of 4th week during 4-week intermittent fasting (CALU, INTS6, KIT, CROCC, PIGR), and 1 week after 4-week intermittent fasting (CALU, CALR, IGFBP4, SEMA4B) compared with the levels before 4-week intermittent fasting

Oral semaglutide shows no significant difference compared with other GLP-1 receptor agonists in the incidence of MACE, in hospitalization for heart failure, and no difference on cardiovascular death (except for Lixisenatide: HR 0.5

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GLP-1 is one more hormone making the case for Paleo or at least, for a focus on hormonal healing when it comes to weight loss, instead of just calorie-counting and white-knuckling it.