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After TBI, the NAD-dependent deacetylase sirtuin-1 (Sirt1) that promotes Nrf2 is downregulated, reducing Nrf2 signaling and Nrf2-induced transcription of antioxidant, antiapoptotic and metabolic genes [80]

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20 ADMA is an endogenous nitric oxide synthase (NOS) inhibitor that can significantly reduce the synthesis of vasodilator NO, leading to the development of cardiovascular disease

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