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-KG is an essential cofactor for -KG-dependent dioxygenases and is required for DNA and histone demethylation (amino acids involved in epigenetic modification will be addressed in section Amino Acid Metabolism and Epigenetics)

Discuss timing with your prescribing physician

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However, the specific metabolic derangements that cause the 5-oxoproline accumulation remain unclear

It shows promise in healing stomach ulcers, alleviating inflammatory bowel disease (IBD), and promoting the closure of various types of fistulas (abnormal connections between organs or to the skin)