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The widespread use of GLP-1 RAs is relatively new, and we dont yet have enough long-term data on these medications to definitively state that long-term use carries no risks
second vial gives margin
Suggested phrasing: preferred wording: Not recommended outside strict indications (ideally within research protocols) and requires time-bounded use with explicit contraception and washout planning. This avoids absolute prohibition while still signaling the expected standard of care
Nat Rev Endocrinol (2011) 8:22836
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