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The Phase 2 VISTA trial demonstrated that Elecoglipron (AZD5004), a once-daily oral small-molecule GLP-1 receptor agonist, achieved up to 11.8% mean weight loss at 36 weeks in adults with obesity or overweight without diabetes
3) Jynarque (tolvaptan) Jynarque is a selective vasopressin V 2 -receptor antagonist designed to decelerate the decline of kidney function in adults who are at risk of experiencing rapid progression of autosomal dominant polycystic kidney disease (ADPKD)
Lingvay has received research funding, advisory/consulting fees and/or other support from Novo Nordisk, and her other disclosures can be found in the manuscript.
Colorectal cancer was reported in: 183 of 140,758 GLP1 users 247 of 140,692 aspirin users Among all participants, GLP-1 drugs reduced the risk of colorectal cancer by 36% compared to aspirin
(42) Long-Term Outcomes of Semaglutide Summary of Recent Trial Results SELECT Trial (2.4 mg): Demonstrated 20% MACE reduction in patients without diabetes, highlighting its effect beyond glycemic control
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