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Menopause weight gain stems from declining estrogen, reduced metabolic rate, and altered appetite regulationcompounding factors that make standard weight-loss approaches less effective

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112,113 In metastatic hormone receptorpositive breast cancer, mutations in the ligand-binding domain (LBD) of estrogen receptor 1 (ESR1), which encodes ER, contribute to treatment resistance

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Most patients can start body contouring treatments within a few weeks of beginning their medication