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Some exploratory research for neurodegenerative diseases, inflammatory bowel disease etc but evidence is preliminary
Washington (DC): National Academies Press
Elevated levels of Propionylcarnitine in serum are an indirect biomarker of vitamin B12 deficiency, because B12 deficiency inhibits the conversion of propionyl-CoA to succinyl-CoA, leading to accumulation of Propionylcarnitine [2]
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In that same study, 29% of people taking metformin daily lost greater than or equal to 5% or more of their initial body weight by the end of the first year, compared with 13% of people in the placebo group
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