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In a transgenic mouse model of mutant alpha-synuclein (A53T), experiments showed that alpha-synuclein accumulation in astrocytes affected glutamate transport, triggering a rise of extracellular glutamatergic concentrations and excitotoxicity, which further exacerbated damage to dopaminergic neurons (Sarafian et al., 2017)
Plasma concentrations fall from roughly 200 ng/mL in young adults to under 80 ng/mL after age 60
Common side effects (SURPASS meta-analysis and SURMOUNT-1 reporting) Side effect Nausea Approx
TB-500 (Thymosin Beta-4 fragment) Explored for inflammation response and tissue repair
Kim SJ, Uehara H, Karashima T, McCarty M, Shih N, Fidler IJ
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