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Despite its therapeutic efficacy, tacrolimus has a narrow therapeutic window (520 ng/mL whole blood 1012 h post-dose) and frequently displays episodes of toxicity, such as nephrotoxicity, neurotoxicity, and glucose intolerance (Chow et al., 1997)
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Avoid combining with strong exfoliating acids or aggressive depigmenting agents unless advised by a professional, as this may increase irritation
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