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If a patients CBC shows anemia that wont go away, we might need to change their vitamin B12 dose or find other causes
[7] [8] Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries
It is posited to be involved in several cellular processes, including the regulation of immune responses and wound healing
The antibodies also attack cells in the mucosal lining (moist inner lining) of your stomach and nerve cells
This happens because certain MTHFR mutations (C667T and A129C) lower the amount of active folate being produced in the body, and the use of vitamin B12 requires the active form of folate
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