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For premenopausal women with regular ovulatory cycles, the ovaries remain the primary source of oestrogen, so the impact of fat loss on total oestrogen levels may be less pronounced, though changes in oestrogen metabolism and distribution can still occur

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PMID 30631755

Cells lacking PCBP1 or PCBP2 exhibit loss of DOHH activity, as measured by the accumulation of partially modified deoxyhypusine and reduced levels of fully modified hypusine (20% of control) in living cells