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Medicare Administrative Contractors (MACs) may publish regional Local Coverage Determinations (LCDs) that add or restrict covered diagnoses beyond the national article

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While large-scale randomized controlled trials (RCTs) have focused on higher-dose protocols for regulatory approval, a growing number of physicians are reporting excellent results at significantly lower doses , especially in individuals who are metabolically healthy or seeking lifestyle optimization rather than aggressive weight loss

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This is because better blood sugar control and weight loss can lead to fewer symptoms of type 2 diabetes, such as fatigue and frequent urination