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There is also a risk of worsening diabetic retinopathy with rapid improvement in blood glucose control
Overall, the paper suggests that the effect of GLP-1-based drugs on muscle appears to be comparable to that of natural weight loss except for the different molecular signature, which may have yet undiscovered long-term effects
"The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions." Lancet Diabetes Endocrinol
Researchers interested in combination formulations may need to explore compounding pharmacy sources like Empower Pharmacy or Olympia Pharmacy
Novo Nordisk is also looking to extend the indications for semaglutide even further, with trials on the go in metabolic dysfunction-associated steatohepatitis (MASH) and Alzheimer's disease.
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