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But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create

For detailed information on the GLP-1 comparison, see how does retatrutide work and retatrutide vs tirzepatide

Note that these two documented starting doses are worlds apart in size 150 mcg versus 2.5 mg is a roughly 17-fold difference

If you experience unexpected effects, double-check your reconstitution math