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The mechanistic case is strong

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After supplementation with DHO or OA (the substrate and product of DHODH), the ferroptosis caused by GPX4 inhibition was attenuated and enhanced, respectively, and these effects were particularly significant in cancer cells with low GPX4 expression

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This approval for Ozempic allows us to more broadly address conditions within cardiovascular-kidney-metabolic syndrome, which affects millions of adults and could have serious consequences if left untreated, said Anna Windle, senior vice president Clinical Development, Medical & Regulatory Affairs at Novo Nordisk

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