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Reduced glutathione (GSH) is oxidized to glutathione disulfide (GSSG) in aqueous solution, and this process is accelerated by exposure to oxygen, light, and elevated temperature

FXR suppresses colorectal cancer by inhibiting the Wnt/-catenin pathway via activation of TLE3

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Where both homocysteine and glutathione are unusually low, it may indicate impaired folate metabolism or reduced activity of enzymes involved in one-carbon metabolism, such as DHFR or MTHFR, rather than representing an ideal metabolic state

doi: 10.3389/fmed.2022.917019 307 SinghIJosephPHeerdtPMCullinanMLutchmansinghDDGulatiMet al