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Cartilage Regeneration and Osteoarthritis Research published in Frontiers in Cell and Developmental Biology investigated the application of FOXO4-DRI in joint degeneration
Lilly's first Phase 3 readout (TRIUMPH4) reported strong results in people with obesity/overweight and knee osteoarthritis, including: ~28.7% average weight loss at 68 weeks at the 12 mg dose (topline reporting), plus improvements in pain and function measures The important phrase there is "topline"
Both may be used for weight management in eligible patients, but they differ in how they work, dosing, side effects, and insurance coverage
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