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Whole foods provide a matrix of nutrients that work synergistically

American Journal of Physiology Renal Physiology 317(6):F1450F1461 Pereira ADS, Miron VV, Castro MFV, Bottari NB, Assmann CE, Nauderer JN, Bissacotti BF, Mostardeiro VB, Stefanello N, Baldissarelli J, Palma TV, Morsch VMM, Schetinger MRC (2023) Neuromodulatory effect of the combination of metformin and vitamin D3 triggered by purinergic signaling in type 1 diabetes induced-rats

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These creams usually contain ingredients like hydroquinone, kojic acid, or vitamin C that help to inhibit the production of melanin in the skin

Bigarella CL, Liang R, Ghaffari S