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It has been extensively characterised in preclinical in-vitro and in-vivo models for its cytoprotective, angiogenic, and anti-inflammatory properties across a range of tissue types

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For example, a 4 - year follow - up study of a randomized controlled trial found that the incidence of POCD in the dexamethasone group was lower than that in the placebo group on the 6th day after surgery and 4 years after surgery

Third, and perhaps most relevant, it promotes fibroblast migration and collagen synthesis , the exact cellular processes needed to rebuild the damaged annulus fibrosus

Zangerolamo et al., 2022)