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These results suggest that GLP-1RAs inhibit bile acid synthesis through SREBP-2 suppression in PA-treated cells, possibly linked to reduced hepatic cholesterol levels following GLP-1RA treatment

Underestimating duty cycle: Even short peaks can matter if repeated frequentlypay attention to how often loads occur, not just their length

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A safer sequence is to reduce ongoing exposure, restore hydration and nutrition, correct bowel dysfunction, evaluate organ safety, address biochemical deficiencies and then retest before escalating treatment

10.1038/s41598-020-72184-3 21 ChenM