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Five (27.8%) of the 18 patients developed low free carnitine during the second follow-up (1 to 2 years) timepoint
But many commercial insurers and most state Medicaid programs do not cover GLP-1s for weight management, citing costs
The flagship trial STEP-1 (published in NEJM , 2021) found a mean weight reduction of ~14.9% of body weight with semaglutide 2.4 mg vs ~2.4% with placebo over 68 weeks ( [12] )
[11] When to seek medical advice : Contact your GP if you experience persistent hyperglycaemia, symptoms of high blood sugar, concerning weight regain, or difficulty managing your eating behaviours
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