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Elevated levels of HNE-protein adducts have been observed both in Lewy bodies within the SN and in the CSF of PD patients (82, 86)
However, the GPI-anchoring module allows the GST fusion to express in the endoplasmic reticulum (ER) lumen and translocate to the out leaflet of the cell membrane through the Golgi apparatus (Kinoshita, 2020), making GST free from the endogenous GSH ligands
In clinical trials of Wegovy, alopecia was reported in about 3% of adult patients on the medication versus 1% on placebo
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