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Diabetes Care 1996
Rats have many physiological and anatomical similarities to humans
Still, further study is required to establish a connection definitively
Many research planning windows are shorter 12 to 24 weeks is common for tolerability and titration assessment, with longer cycles for efficacy endpoints
They also represent a direct collision between the professional judgment of career FDA scientists and a reconstituted advisory committee whose composition had drawn intense scrutiny before the meeting even opened
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