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This mechanistic complexity, coupled with the translational gap between animal models and clinical practice, has repeatedly undermined single-target strategies and continues to limit the development of effective therapies

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Reducing the proliferation of breast cancer cells by blocking this cascade, which was accomplished by lowering the expression levels of YAP gene targets ( Figure 1 The antioxidant resveratrol repressed SRY-box 2, blocked AKT, and inhibited signal transducer and activator of transcription 3 signalling, among other effects