Bottom Line Semaglutide side effects are real, and it's worth going in with clear expectations
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Before prescribing tirzepatide, ensure patients understand: The difference between expected side effects (nausea, GI symptoms) and allergic reactions Warning signs requiring immediate medical attention The importance of having emergency contact information readily available Proper injection technique according to the device Instructions for Use Ongoing monitoring should include assessment for hypersensitivity symptoms at follow-up visits, particularly during dose escalation
Side effects may temporarily return with dose increases but are usually milder than initial onset