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A lack of antioxidants, such as glutathione, may aggravate cell death in the liver
Target: the FOXO4-p53 protein interaction in senescent cells
The modular design prospects, moreover, allow for the adoption of co-delivery strategies in one system
and (ii) at least two non-enzymatic amphipathic antioxidants selected from the group consisting of: beta-carotene, vitamin E, vitamin C, glutathione, niacin, and N-acetyl-cysteine, in an amount of sufficient to deliver 0.0005-1.0 g beta-carotene per kg body weight, 0.001-10 g vitamin E per kg body weight, 0.001-2.0 g vitamin C per kg body, 0.001-2.0 g glutathione per kg body weight, 1-1000 mg niacin per kg body weight and 0.003-6.0 g N-acetyl-cysteine per kg body weight, wherein the disease or injury is selected from the group consisting of: acute respiratory distress syndrome, ischemia-reperfusion injury, hemorrhagic shock, tissue injury induced by inflammation, and tissue injury induced by a chemical agent or a caustic agent, and wherein the amphipathic antioxidant composition quenches free radicals and reduces the damage induced by the pathological free radical reactions
Used needles and syringes should be placed in an FDA-cleared puncture-proof sharps container rather than household trash to prevent needle-stick injuries
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