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Concordantly with the pharmacological experiments, GCLM deficiency reduced cellular tolerance to FA, which could be reverted by expressing GCLM in trans (Fig
The SASP Factor: Senescent cells stop dividing but remain metabolically active, churning out a SASP (Senescence-Associated Secretory Phenotype) cocktail of pro-inflammatory cytokines that turn neighboring healthy cells into senescent ones
Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL, and Drucker DJ
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