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607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment
Grecki, D.C., M
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Future directions for clinical management and patient care Personalized medicine Personalized medicine, leveraging genomics, metabolomics, and other multi-omics approaches, holds significant promise for the early diagnosis and therapeutic monitoring of DN
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