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if neurological involvement is present, maintenance is every two months Oral therapy is generally not appropriate where absorption is impaired (e.g., pernicious anaemia), as adequate levels cannot be reliably achieved Because B12 is water-soluble and any excess beyond hepatic storage capacity is excreted in the urine, it has a low toxicity profile

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Tetracycline-Class Antibiotics: The Absolute Contraindication Co-prescribing isotretinoin with any tetracycline antibiotic (doxycycline, minocycline, tetracycline, demeclocycline, sarecycline) is contraindicated

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