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This data suggests that while lower doses (5-15g) are excellent for maintenance and mild IBS, repairing severe, pathological "leaky gut" may require transient, high-dose interventions under medical supervision to rapidly force the reassembly of tight junction proteins

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Vitamin B12 deficiency can be caused by blood count changes such as hyperchromic macrocytic megaloblastic anemia or nerve damage, e.g

Hair changes can reflect many things B12 is worth checking, but it's not the only possibility