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Researchers have investigated SLU-PP-332 due to its potential influence on oxidative metabolism, mitochondrial biogenesis, energy expenditure, and skeletal muscle physiology
Ivermectin is not recommended in children younger than 5 years or less than 15kg in weight due to a theoretical risk of CNS adverse events
The real challenge lies in identifying metabolic/PCD internal phenotypes that are more likely to benefit from Nrf2 or mTOR/AMPK regulation in the highly heterogeneous COPD population, using oxidative stress biomarkers (such as 8-iso-PGF 2 , MDA), iron metabolism indicators, mitochondrial function, and autophagic flux-related biological markers, and implementing time-limited interventions within appropriate time windows (such as during acute exacerbation recovery or in high-risk stable populations), rather than long-term, indiscriminately pulling these basic metabolic pathways (298, 299)
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