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Neither study showed a significant increase in amylase (7% for both studies) or lipase (28% in the LEADER trial and 31% in the SCALE trial) values after starting liraglutide compared with placebo, and the positive predictive values of amylase and lipase for pancreatitis were less than 1%

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The 12mg maximum is lower than tirzepatide but achieves greater efficacy, demonstrating that three receptor targets provide synergistic effects beyond what raw dosing would suggest

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Some people may be more likely to experience serious side effects when taking liraglutide, including people who take insulin or have (or have had) kidney or gallbladder problems

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