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In adjusted analyses, semaglutide reduced epigenetic aging across multiple second- and third-generation clocks, including PhenoAge ( 4.9 years/year, p = 0.004), PCGrimAge ( 3.1, p = 0.007), GrimAge V2 ( 2.3, p = 0.009), OMICmAge ( 2.2, p = 0.009), RetroAge ( 2.2, p = 0.030), and DunedinPACE ( 0.09 units, 9% slower, p = 0.01)
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If youre struggling with weight gain during midlife, please know this: its not your fault, and its not just about willpower or working out more
2026;15(1):e70001
While on the medication, she established healthier eating habits and incorporated excerise into her routine
